Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery
نویسندگان
چکیده
منابع مشابه
Mesenchymal Stem Cells as Gene Delivery Vehicles
Mesenchymal stem cells (MSCs) possess a battery of unique properties which make them ideally suited not only for cellular therapies/regenerative medicine, but also as vehicles for gene delivery in a wide array of clinical settings. These include: 1) widespread distribution throughout the body; 2) ease of isolation and ability to be extensively expanded in culture without loss of potential; 3) t...
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Heart failure is one of the leading causes of death worldwide. End stage disease often requires heart transplantation, which is hampered by donor organ shortage. Tissue engineering represents a promising alternative approach for cardiac repair. For the generation of artificial heart muscle tissue several cell types, scaffold materials and bioreactor designs are under investigation. In this revi...
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Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a new therapeutic for treating a variety of immune-mediated diseases. First heralded as a regenerative therapy for skeletal tissue repair, MSCs have recently been shown to modulate endogenous tissue and immune cells. Preclinical studies of the mechanism of action suggest that the therapeutic effects afford...
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there is increasing trend in using recombinant stem cells as novel therapeutic candidates in different diseases. these studies encompass different applications from targeted homing of mesenchymal stromal (stem) cells (msc), to arming them with different cytokines. resistance to transfection or transduction methods had urged researchers to look for better gene delivery alternates and optimizing ...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2010
ISSN: 0169-409X
DOI: 10.1016/j.addr.2010.08.010